Surrounded by a forest and a gated entrance, the Grace Field House is inhabited by orphans happily living together as one big family, looked after by their "Mama," Isabella. Although they are required to take tests daily, the children are free to spend their time as they see fit, usually playing outside, as long as they do not venture too far from the orphanage—a rule they are expected to follow no matter what. However, all good times must come to an end, as every few months, a child is adopted and sent to live with their new family, never to be heard from again. However, the three oldest siblings have their suspicions about what is actually happening at the orphanage, and they are about to discover the cruel fate that awaits the children living at Grace Field, including the twisted nature of their beloved Mama. [Written by MAL Rewrite]

Dr. Kenzou Tenma, an elite neurosurgeon recently engaged to his hospital director's daughter, is well on his way to ascending the hospital hierarchy. That is until one night, a seemingly small event changes Dr. Tenma's life forever. While preparing to perform surgery on someone, he gets a call from the hospital director telling him to switch patients and instead perform life-saving brain surgery on a famous performer. His fellow doctors, fiancée, and the hospital director applaud his accomplishment; but because of the switch, a poor immigrant worker is dead, causing Dr. Tenma to have a crisis of conscience. So when a similar situation arises, Dr. Tenma stands his ground and chooses to perform surgery on the young boy Johan Liebert instead of the town's mayor. Unfortunately, this choice leads to serious ramifications for Dr. Tenma—losing his social standing being one of them. However, with the mysterious death of the director and two other doctors, Dr. Tenma's position is restored. With no evidence to convict him, he is released and goes on to attain the position of hospital director. Nine years later when Dr. Tenma saves the life of a criminal, his past comes back to haunt him—once again, he comes face to face with the monster he operated on. He must now embark on a quest of pursuit to make amends for the havoc spread by the one he saved. [Written by MAL Rewrite]

For weeks, Atsushi Nakajima's orphanage has been plagued by a mystical tiger that only he seems to be aware of. Suspected to be behind the strange incidents, the 18-year-old is abruptly kicked out of the orphanage and left hungry, homeless, and wandering through the city. While starving on a riverbank, Atsushi saves a rather eccentric man named Osamu Dazai from drowning. Whimsical suicide enthusiast and supernatural detective, Dazai has been investigating the same tiger that has been terrorizing the boy. Together with Dazai's partner Doppo Kunikida, they solve the mystery, but its resolution leaves Atsushi in a tight spot. As various odd events take place, Atsushi is coerced into joining their firm of supernatural investigators, taking on unusual cases the police cannot handle, alongside his numerous enigmatic co-workers. [Written by MAL Rewrite]

Shinichi Kudou, a high school student of astounding talent in detective work, is well known for having solved several challenging cases. One day, when Shinichi spots two suspicious men and decides to follow them, he inadvertently becomes witness to a disturbing illegal activity. Unfortunately, he is caught in the act, so the men dose him with an experimental drug formulated by their criminal organization, leaving him to his death. However, to his own astonishment, Shinichi lives to see another day, but now in the body of a seven-year-old child. Perfectly preserving his original intelligence, he hides his real identity from everyone, including his childhood friend Ran Mouri and her father, private detective Kogorou Mouri. To this end, he takes on the alias of Conan Edogawa, inspired by the mystery writers Arthur Conan Doyle and Ranpo Edogawa. Detective Conan follows Shinichi who, as Conan, starts secretly solving the senior Mouri's cases from behind the scenes with his still exceptional sleuthing skills, while covertly investigating the organization responsible for his current state, hoping to reverse the drug's effects someday. [Written by MAL Rewrite]